The Former Barcelona, Arsenal and Chelsea midfielder last played for Como in Serie B.
The former Spain international played active football for 20 years and won major trophies with Arsenal, Barcelona and Chelsea.
He lifted the two FA Cups, two Premier League titles and one LaLiga crown.
Fabregas also won the World Cup and European Championship trophies with Spain.
In a statement, the 36-year-old said: “It is with great sadness that the time has come for me to hang up my playing boots.
“From lifting the World Cup, the Euros, to winning everything in England and Spain and nearly all the European trophies, it has been a journey that I’ll never forget.
“After 20 incredible years full of sacrifice, dedication and joy, it’s time to say thank you and goodbye to the beautiful game.”